Detection of Epidermal Growth Factor Receptor Mutations in Samples obtained with Endobronchial Ultrasound‐Guided Transbronchial Needle Aspiration: A Short Review

Garcia-Olive I, Sanz-Santoz J, Andreo F, Monso E. Detection Of Epidermal Growth Factor Receptor Mutations In Samples Obtained With Endobronchial Ultrasound-Guided Transbronchial Needle Aspiration: A Short Review. Annals of Respiratory Medicine, February 2010; 1(1):85-88

Review Article

Ignasi Garcia‐Olivé ^{1 2}, José Sanz‐Santos ¹, Felipe Andreo ^{1 3} and Eduard Monsó ^{1 3}
Affiliations: ¹Respiratory Service, Hospital Universitari Germans Trias i Pujol, Badalona, Catalunya, Spain; ²Departament de Medicina, Universitat Auto`noma de Barcelona, Spain and ³Ciber de Enfermedades Respiratorias—CibeRes, Bunyola, Spain


ABSTRACT

The presence of somatic mutations of the tyrosine kinase (TK) domain of epidermal growth factor receptor (EGFR) gene in patients with advanced non‐small cell lung cancer (NSCLC) correlates with a good response to TK inhibitors. The objective of this review was to assess the usefulness of real‐time endobronchial ultrasound‐guided transbronchial needle aspiration (EBUS‐TBNA) in detecting EGFR mutations in cells recovered from malignant mediastinal nodes from patients with lung adenocarcinoma. A systematic review was carried out in September 2009, and we found that two studies had investigated the usefulness of EBUS‐TBNA for obtaining tissue samples from mediastinal and hilar nodes to analyze EGFR gene mutations. Most patients had advanced‐stage disease. The feasibility of performing an EGFR gene analysis of the EBUS‐TBNA sample ranged from 72.2% to 93.5% in patients with lymph node metastases. Prevalence of EGFR mutations ranged from 9.8% to 25.6%. In conclusion, samples obtained by EBUS‐TBNA in patients with lung adenocarcinoma are suitable for the detection of EGFR gene mutations.

Keywords: real‐time endobronchial ultrasonography needle aspiration (EBUS), epidermal growth factor receptor (EGFR), adenocarcinoma, lung cancer
Correspondence: Ignasi Garcia‐Olivé, Respiratory Service, Hospital Germans Trias i Pujol, Carretera de Canyet s/n, 08916 Badalona, Catalunya, Spain. Tel: (34)‐934‐978920; Fax: (34)‐934‐978722; e‐mail: ignasi.g.olive@gmail.com